Beilstein J. Org. Chem.2022,18, 1017–1025, doi:10.3762/bjoc.18.102
of their biosynthetic mechanisms.
Keywords: biosynthesis; methyltransferase; naturalazoxides; reactivity-based screening; Streptomyces; Introduction
Azoxy natural products are a rare yet intriguing class of natural products with various beneficial biological properties, such as antibacterial
biosynthetic pathways and structural diversity of aliphatic azoxy natural products. Considering that most groups in the SSN lack links to their biosynthetic products, a substantial fraction of the chemical diversity in aliphatic naturalazoxides likely remains untapped.
Conclusion
By using the generation of
discovery. Bioinformatic surveys shed light on the unexplored biosynthetic potential of actinobacteria for aliphatic azoxides, setting the stage for the targeted isolation of this scarce yet valuable class of natural products with remarkable biological activities.
Representative naturalazoxides